As shown in Fig. 2(a), an increase

As shown in Fig. 2(a), an increase both in temperature and
amount of water cosolvent were strongly positively correlated with
an increase in the inactivation yield of spores at a fixed treatment
time (30 min). In particular, the increase in diffusivity of SC-CO2 and
the higher rate of chemical reaction at a higher temperature (Liao
et al., 2010) may have enhanced the lethal effect of SC-CO2, such as
the higher penetration of SC-CO2 inside cells (Hong and Pyun,
1999), the malfunction of efflux pumps and disruption of membrane
integrity (Kim et al., 2009a), and the deactivation of proteins and enzymes