• The VDR Recent studies have shown that vitamin D supplementation protects mice from diet-induced steatosis and VDR KO mice spontaneously develop hepatic steatosis [94, 95]. Polymorphisms in VDR are associated with HCC development in patients with alcoholic cirrhosis, and VDR activation acts antiproliferative effects [96, 97]. In HCV patients, low and the VDR regulates T-cell activation [97, 98]factors. Specific ligands of most NRs are known, arehas anti-inflammatory effects and (in mice) inducesNR, PPARα is known to be the receptor for fibrates indiacylglycerol has been identified as an endogeneousin liver tissue, and liver-specifichas anti-inflammatory features as it represses NFκBbeen identified to play a central role in hepatic lipidmethionine- and choline- deficient diet (MCD), a modelFXR activation induces secretion of fibroblast growthdietary lipids and fine-tune their metabolismanti-inflammatory attributes as it modulates the innateis a novel target in the field of hepatology.vitamin D levels are associated with fibrosis progression,
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