The severity of congestive heart failure might arisewhen this downregulation of the β-adrenergic-signallingsystem coincides with a Ca2+-induced Ca2+-signallingremodelling process to switch off the expression of keycomponents such as the SERCA pumps. It is the coincidence of these two regulatory events that might explainthe severe disfunction of the Ca2+uptake and storagecapacity, which results in the weak transients that characterize the failing human heart11
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