PathophysiologyThrombocytopenia may be defined as a subnormal number ofplatelets in the circulating blood. It is the most common causeof abnormal bleeding. Despite the number and diversity of disordersthat may be associated etiologically, thrombocytopeniaresults from only four processes: artifactual thrombocytopenia,deficient platelet production, accelerated platelet destruction, andabnormal distribution or pooling of the platelets within the body(Fig. 46.1). The changes in the basic parameters of thrombopoiesisthat are characteristic of each of these processes are summarizedin Table 46.1.
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