Recommendation. First-generation H1-blockers like chlorpheniramine,dexchlorpheniramine, mebhydroline, clemastine, and dimetindene can beused during pregnancy for the treatment of allergic conditions. As the best-studied second-generation antihistamine, loratadine can be used duringpregnancy for the treatment of allergic conditions. Cetirizine could be anacceptable second choice. It should be noted that neonatal respiratorydepression has been reported after perinatal use of some first-generationantihistamines. To date, the inadvertent use of the new and/or less well-documented antihistamines does not require termination of pregnancy orinvasive diagnostic procedures. When feasible, local treatment withintranasal sodium cromoglycate, beclomethason or budesonide is preferredin conditions like allergic rhinitis etc
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