PG denotes pseudogene (in italic) and MP denotes that missensemutations have been described. Those marked MP in italic are presenton the Human CYP allele nomenclature Committee web page(http://www.imm.ki.se/CYPalleles/). nd not described like Arabidopsis with 239 P450 genes and rice with 458P450 genes. The cytochrome P450 based detoxification potentialappears to be higher in rodents and the recently completedmouse genome revealed 108 functional CYP genes.The background might be inherent in a higher need formetabolism of dietary components.As evident from Table 1 it is apparent that there is adifference between the characteristics of genes encodingxenobiotics metabolism (CYP1–3) and those of importancefor the metabolism of endogenous compounds. The numberof pseudogenes are by far most apparent in the CYP2
đang được dịch, vui lòng đợi..
