On these films, many show evidence ofsome instability as described by Harris and Macnab (1954) but none has as yet complained into the disc ashigh as 16 milligrams. We have been gradually reducing the dosage to find the minimalamount that is effective. A dose of 2 milligrams per disc is adequate. It is reassuring that2 milligrams can be injected intrathecally in a five-pound rhesus monkey without acute orchronic ill effects.Recently, a temporary rise in urinary acid mucopolysaccharide excretion has been detectedin our patients after chemonucleolysis. Excretion is increased approximately one or two foldfor one to three days after injection, after which it recedes to pre-injection levels. The increaseis largely in the chondroitin sulphate C fraction. We believe this substance represents absorptionproducts from the displaced disc material ; if this is so, such a comparatively simple method ofrelieving this disability is most appealing.Other clinicians are starting investigations in humans with this method of chemicalattack upon intervertebral disc lesions. We await their confirmation of our experiences.
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