Mitochondrial activity has a major impact on the IRP and oxidant load. Thisimpact is complex and multifaceted as mitochondrial function influences thelevels of NAD(P)H, intermediary metabolites as well as ROS. The contribution of these factors will depend on the physiological environment of the cell and as such is subject to change as oocytes and embryos develop.The shuttling of NADH between the mitochondrial and cytosolic compartments is essential for normal cell function.
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