ESOMEPRAZOLE Indicationsseeunder DoseCautionsseenotesabove;interactions:Appendix1(protonpumpinhibitors)Hepaticimpairmentinseverehepaticimpairmentmax.20mgdaily(CHILD1–12yearsmax.10mgdaily);forseverepepticulcerbleedinginseverehepaticimpairment,initialintravenousinfusionof80mg,thenbycontinuousintravenousinfusion,4mg/hourfor72hoursRenalimpairmentmanufactureradvisescautioninsevererenalinsufficiencyPregnancymanufactureradvisescaution—noinfor-mationavailableBreast-feedingmanufactureradvisesavoid—noinformationavailableSide-effectsseenotesaboveDose.BymouthduodenalulcerassociatedwithHelicobacterpylori,seeeradicationregimensonp.51NSAID-associatedgastriculcer,ADULTover18years,20mgoncedailyfor4–8weeks;prophylaxisinpatientswithanincreasedriskofgastroduodenalcomplicationswhorequirecontinuedNSAIDtreat-ment, 20mgdailyGastro-oesophagealrefluxdisease (inthepresenceoferosiverefluxoesophagitis), ADULTandCHILDover12years, 40mgoncedailyfor4weeks, continuedforfurther4weeksifnotfullyhealedorsymptomsper-sist; maintenance20mgdaily; CHILD1-12years, cơ thể-weight10-20kg, 10mgoncedailyfor8weeks; cơ thể-weightover20kg, 10-20mgoncedailyfor8weeksSymptomatictreatmentofgastro-oesophagealrefluxdisease (intheabsenceofoesophagitis), ADULTandCHILDover12years, 20mgoncedailyforupto4weeks, then20mgdailywhenrequired; CHILD1–12years,body-weightover10kg,10mgoncedailyforupto8weeksZollinger–Ellisonsyndrome,ADULTover18years,initially40mgtwicedaily,adjustedaccordingtoresponse;usualrange80–160mgdaily(above80mgin2divideddoses). Byintravenousinjectionoveratleast3minutesorbyintravenousinfusion,ADULTover18years,gastro-oesophagealrefluxdisease,40mgoncedaily;symp-tomaticrefluxdiseasewithoutoesophagitis,treat-mentofNSAID-associatedgastriculcer,preventionofNSAID-associatedgastricorduodenalulcer,20mgdaily;continueuntiloraladministrationpossible. Severepepticulcerbleeding(followingendoscopictreatment),ADULTover18years,initialintravenousinfusionof80mgover30minutes,thenbycontinu-ousintravenousinfusion8mg/hourfor72hours,thenbymouth40mgoncedailyfor4weeksEsomeprazole(Non-proprietary)ACapsules,enclosinge/cpellets,esomeprazole(asmagnesiumsalt)20mg,netprice28-cappack=£5.30;40mg,28-cappack=£6.57.Counselling,administrationBrandsincludeEmozul®CounsellingDonotcheworcrushcapsules;swallowwholeormixcapsulecontentsinwateranddrinkwithin30minutes;foradministrationthroughagastrictube,consultproductliteratureTablets,e/c,esomeprazole(asmagnesiumsalt)20mg,netprice28-tabpack=£5.31;40mg,28-tabpack=£6.58.Counselling,administrationCounsellingDonotcheworcrushtablets; swallowwholeordisperseinwateranddrinkwithin30minutes; foradministrationthroughagastrictube, consultproductliteratureInjection, powderforreconstitution, esomeprazole (assodiumsalt), netprice40-mgvial = £3 .10Nexium ® (AstraZeneca) ATablets, e/c, f/c, esomeprazole(asmagnesiumtri-hydrate) 20 mg (lightpink), netprice28-tabpack = £18,50; 40 mg (màu hồng), 28-tabpack = £25.19.Counsel-ling,administrationCounsellingDonotcheworcrushtablets; swallowwholeordisperseinwateranddrinkwithin30minutes; foradministrationthroughagastrictube, consultproductliteratureGranules, màu vàng, e/c, 10mg/sachet,netprice28-sachetpack=£25.19.Label:25,counselling,administrationCounsellingDispersethecontentsofeachsachetinapprox.15mLwater.Stirandleavetothickenforafewminutes esomeprazole (asmagnesiumtrihydrate); stiragainbeforeadministrationandusewithin30minutes; rinsecontainerwith15mLwatertoobtainfulldose; foradministrationthroughagastrictube, consultproductliteratureInjection, powderforreconstitution, esomeprazole (assodiumsalt), netprice40-mgvial = £4,25
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