In most of the structures so far solved, recognition involves the TCR lying either diagonally or orthogonally (Figure 5.22b,c) across the peptide–MHC with the TCRVα CDR1 and CDR2 overlying the MHC class II β1-helixor class I α2-helix, and the Vβ CDR1 and CDR2 overlying the α1-helix of MHC class I or class II (Figure 5.23)
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