This group of polymers usually comprises polybases (i.e. polyamines, polyethylenemine) whichmay bear amine groups in their side chains that accept protons at acidic pH and donate protons atbasic pH [86]. Poly(N,N’-diethylaminoethyl methacrylate) [56] and poly(N,N’-dimethylaminoethyl methacrylate) (PDMAEMA) [87] are examples of polybases bearingcationic polymers, Table 1. The tertiary nitrogen of amino group plays an important role in thepH sensitivity of cationic polymers. Yang and coauthors synthesized cationic triblock polymerssuch as poly (ε-caprolactone) -PDMAEMA-(poly (PEG) methyl-ether-methacrylate), which self assembledto form pSM for the intracellular delivery of DOX.
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