Until 1980, tetracyclines, sometimes used in combination with trypan blue, and cephaloridine were recommended for treatment of feline babesiosis. In 1981 Potgieter investigated the efficacy of 10 drugs for treating B. felis infections. Primaquine phosphate (Primaquine, Centaur), administered per os or intramuscularly was found to be highly effective and the obvious drug of choice. The side- and toxic effects of primaquine are undesirable, however. It frequently causes vomition when administered orally and mortality if administered in doses exceeding 1 mg/kg. Additionally, primaquinedoesnotsterilisetheparasite infection.
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