The committed step of fatty-acid biosynthesis requires the activation of acetyl-CoA to malonyl-CoA. This is an energy-consuming process catalysed by acetyl-CoA carboxylase (ACC). The acetyl and malonyl groups are then coupled to the acyl-carrier protein domain of the multifunctional enzyme fatty-acid synthase (FASN). Repeated condensations of acetyl groups generate basic 16-carbon saturated fatty acids (palmitic acid).
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