Central Nervous System effects due to reduced sympathetic outflow e.g. malaise; vivid dreams, nightmares and, rarely, hallucinations with highly lipid soluble beta-blockers which have greater penetration into the Central Nervous System Masking of hypoglycaemia in insulin-dependent diabetes because of blunting of sympathetic nervous activation. Mainly non-selective agents. Hyperglycaemia Risk of new onset diabetes
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