These fatty acids are considered essential and should be provided by the diet or from supplements. They compete with the arachidonic acid (AA), a member of the omega-6 family through the same enzymatic pathway and stimulate series 3 prostaglandins and series 5 leukotrienes, which have a lower inflammatory action than those AA-derived eicosanoids.6Several studies have demonstrated that omega-3 fatty acids can reduce the concentrations of C reactive protein (CRP), proinflammatory eicosanoids, cytokines, chemokines, and other inflammatory biomarkers.7–10 In addition, eicosa-pentaenoic acid (EPA) and docosahexaenoic acid (DHA), both members of omega-3 family, are precursors of the lipid medi-ators resolvins and protectins, which have anti-inflammatory and immunomodulatory characteristics.11–13In view of these properties, supplements with this class of lipids might represent an additional therapy of systemic chronic inflammatory diseases, such as systemic lupus ery-thematosus (SLE) and other rheumatic conditions. Studies conducted in subjects with rheumatoid arthritis report an improvement in general physical evaluation, pain, morning stiffness and reduced anti-inflammatory agent use following supplementation with omega-3.1
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