If 1 millilitre perkilogram of cerebrospinal fluid is removed by cisternal puncture the pressure will drop andthe animal will survive with no neurological sequelae; necropsy done months later shows noabnormal features. This sequence was confirmed by Macnab (1965) in another way. Afterlaminectomy in a rabbit, a one-quarter inch square window was cut in the dura and, with along, bent needle, 30 milligrams of chymopapain were instilled intrathecally through thewindow one and a half inches cephalad. This dose was 300 times the lethal intrathecal doseTHE JOURNAL OF BONE AND JOINT SURGERY
đang được dịch, vui lòng đợi..
