epatitis C virus (HCV) treatment is

epatitis C virus (HCV) treatment is rapidly changing but little is known about patients' attitudes and knowledge about HCV. This study used a cross-sectional survey to examine the relationship between HCV knowledge and attitudes towards HCV in patients with HCV mono-infection and HIV/HCV co-infection. Subsequently, an education intervention was developed with an abridged version of the cross-sectional survey administered before and after the education session to assess changes in knowledge and attitudes. 292 people participated in the cross-sectional survey, and 87 people participated in the education intervention. In the cross-sectional survey, the mean knowledge score regarding HCV was low (

Kết quả (Việt) 1:

epatitis C virus (HCV) điều trị thay đổi nhanh chóng nhưng ít được biết về Thái độ và kiến thức về HCV bệnh nhân. Nghiên cứu này sử dụng một cuộc khảo sát mặt cắt để kiểm tra mối quan hệ giữa kiến thức HCV và Thái độ đối với HCV bệnh nhân HCV mono-nhiễm trùng và nhiễm trùng HIV/HCV đồng. Sau đó, một sự can thiệp của giáo dục được phát triển với một phiên bản rút gọn của các cuộc khảo sát mặt cắt quản lý trước và sau khi phiên họp giáo dục để đánh giá các thay đổi trong kiến thức và Thái độ. 292 người tham gia vào các cuộc khảo sát mặt cắt, và 87 người tham gia trong cuộc can thiệp của giáo dục. Trong cuộc khảo sát mặt cắt, số điểm có nghĩa là kiến thức liên quan đến HCV là thấp (< 50% của tổng số điểm có thể). Cá nhân nhiễm mono và bị nhiễm bệnh cùng chia sẻ tương tự kiến thức thâm hụt và Thái độ đối với HCV mặc dù có sự khác biệt cá nhân riêng biệt. Thái độ ủng hộ bệnh nhân bao gồm những điều sau đây: 57% sợ những hậu quả của HCV trên cuộc sống của họ, 37% cảm thấy HCV đã không gây tử vong, 27% không tin họ cần HCV thuốc, 21% cảm thấy xấu hổ của việc có HCV và 16% cảm thấy HCV điều trị đã không quan trọng. Thái độ phản ánh sự thờ ơ và xấu hổ đối với HCV được kết hợp với điểm số thấp hơn kiến thức (HCV kiến thức điểm 15.1 vs 17,5, P < 0,01 cho sự thờ ơ và 15.3 vs 17.2 xấu hổ, P = 0,02). Sự can thiệp của giáo dục cải thiện kiến thức điểm nhưng không đã làm thay đổi thái độ đánh giá. Nghiên cứu sự can thiệp là cần thiết để có hiệu quả thay đổi thái độ đối với HCV nhiễm trùng và điều trị.IntroductionHepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections are preventable and treatable. In the United States, an estimated 3.2 million people live with chronic hepatitis C currently and 20 000 new cases are reported each year.[1] Nearly 8000 Americans die each year from HCV-related complications such as hepatocellular carcinoma, decompensated cirrhosis and liver failure.[2] With the advent of direct-acting antiviral agents such as boceprevir and telaprevir, 59–73% of patients may be cured of hepatitis C infection after treatment, as measured by the sustained virological response (SVR).[3–6] Achieving SVR is associated with reduced incidence of hepatocellular carcinoma and liver-related morbidity and mortality.[7–10] Similar SVR outcomes are observed in patients co-infected with HCV and HIV,[11] in whom chronic liver disease is becoming increasingly important as AIDS-related deaths have decreased with the use of highly active antiretroviral therap.[12]Nevertheless, many of those who are 'mono-infected' with HCV and those 'co-infected' with both HCV and HIV have low rates of obtaining treatment for HCV. Health outcome analysis projects that current treatment patterns will prevent only 14.5% of liver-related deaths attributed to hepatitis C between 2002 and 2030,[13] suggesting that efforts to increase treatment rates are needed to decrease liver-related mortality. Understanding barriers to HCV treatment is important not only for this long-term goal of decreasing mortality but also for patients' ongoing quality of life.[14] Studies have identified both knowledge (information) and attitudes (motivation) as major factors that influence behaviour related to HIV therapy adherence and are best described by the Information Motivation Behavioral skills (IMB) model.[15] For instance, being afraid and feeling asymptomatic were prominent reasons for inadequate follow-up care for people with HIV.[16] More importantly, improving knowledge and motivational states has been shown to help patients with HIV form action plans for maintaining care.[17] The IMB model can be used as a theoretical framework for the understanding of treatment barriers found in those with HCV infection.Barriers to HCV treatment exist in both HCV mono-infected and HIV/HCV co-infected patients. The aim of this study was to first evaluate knowledge and attitude differences between these two groups, second to examine the association between knowledge and attitudes and lastly to design and implement an education intervention that would modify knowledge deficits or attitudes related to HCV infection or treatment.

Kết quả (Việt) 2:

epatitis C virus (HCV) treatment is rapidly changing but little is known about patients' attitudes and knowledge about HCV. This study used a cross-sectional survey to examine the relationship between HCV knowledge and attitudes towards HCV in patients with HCV mono-infection and HIV/HCV co-infection. Subsequently, an education intervention was developed with an abridged version of the cross-sectional survey administered before and after the education session to assess changes in knowledge and attitudes. 292 people participated in the cross-sectional survey, and 87 people participated in the education intervention. In the cross-sectional survey, the mean knowledge score regarding HCV was low (<50% of the total possible score). Mono-infected and co-infected individuals shared similar knowledge deficits and attitudes towards HCV despite having distinct demographic differences. Attitudes endorsed by patients included the following: 57% feared the consequences of HCV on their life, 37% felt HCV was not fatal, 27% did not believe they needed HCV medication, 21% felt ashamed of having HCV and 16% felt HCV treatment was not important. Attitudes that reflected indifference and shame towards HCV were associated with lower knowledge scores (HCV knowledge score of 15.1 vs. 17.5, P < 0.01 for indifference and 15.3 vs. 17.2 for shame, P = 0.02). The education intervention improved knowledge scores but did not modify the assessed attitudes. Intervention studies are needed to effectively change attitudes towards HCV infection and treatment.

Introduction

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections are preventable and treatable. In the United States, an estimated 3.2 million people live with chronic hepatitis C currently and 20 000 new cases are reported each year.[1] Nearly 8000 Americans die each year from HCV-related complications such as hepatocellular carcinoma, decompensated cirrhosis and liver failure.[2] With the advent of direct-acting antiviral agents such as boceprevir and telaprevir, 59–73% of patients may be cured of hepatitis C infection after treatment, as measured by the sustained virological response (SVR).[3–6] Achieving SVR is associated with reduced incidence of hepatocellular carcinoma and liver-related morbidity and mortality.[7–10] Similar SVR outcomes are observed in patients co-infected with HCV and HIV,[11] in whom chronic liver disease is becoming increasingly important as AIDS-related deaths have decreased with the use of highly active antiretroviral therap.[12]

Nevertheless, many of those who are 'mono-infected' with HCV and those 'co-infected' with both HCV and HIV have low rates of obtaining treatment for HCV. Health outcome analysis projects that current treatment patterns will prevent only 14.5% of liver-related deaths attributed to hepatitis C between 2002 and 2030,[13] suggesting that efforts to increase treatment rates are needed to decrease liver-related mortality. Understanding barriers to HCV treatment is important not only for this long-term goal of decreasing mortality but also for patients' ongoing quality of life.[14] Studies have identified both knowledge (information) and attitudes (motivation) as major factors that influence behaviour related to HIV therapy adherence and are best described by the Information Motivation Behavioral skills (IMB) model.[15] For instance, being afraid and feeling asymptomatic were prominent reasons for inadequate follow-up care for people with HIV.[16] More importantly, improving knowledge and motivational states has been shown to help patients with HIV form action plans for maintaining care.[17] The IMB model can be used as a theoretical framework for the understanding of treatment barriers found in those with HCV infection.

Barriers to HCV treatment exist in both HCV mono-infected and HIV/HCV co-infected patients. The aim of this study was to first evaluate knowledge and attitude differences between these two groups, second to examine the association between knowledge and attitudes and lastly to design and implement an education intervention that would modify knowledge deficits or attitudes related to HCV infection or treatment.