Materials and Methods: Thirty patients were randomizedinto two groups: control and laser. LLLT wasperformed three times a week in the laser group, whilecontrol group received sham irradiation. OM severity wasassessed according to the World Health Organization(WHO) and National Cancer Institute (NCI) scales. Proin¯ammatory and anti-in¯ammatory cytokines (TNF-a,IL-6, IL-1b, IL-10, TGF-b), growth factors (EGF, FGF,VEGF), and metalloproteinases (MMP2/TIMP2, MMP9/TIMP2) concentrations were assessed using ELISA test.Saliva samples were collected on admission, and at the 7th,21st, and 35th sessions of radiotherapy.
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