Fig. 2: The mechanisms by which Bordetella dermonecrotic toxin (DNT) enters cells and deamidates/polyaminates Rho. After binding to a putative receptor, DNT is internalized by endocytosis. The toxin undergoes intramolecular cleavage by furin, probably while it is in the endocytotic vesicle, and then enters the cytoplasm by passing across the vesicular membrane. Once in the cytoplasm, DNT deamidates or polyaminates Rho GTPase.
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