AbsorptionThe total systemic clearance is around 110 mL/min and the renal clearance constitutes about 75% of the plasma clearance. No metabolites of sodium clodronate have been found in the urine, indicating that it is not metabolised, and that the administered drug is the active moiety.The average volume of distribution is 20 L. This is about 25% of body weight, equivalent to the extracellular water volume. The plasma protein binding of clodronate is low.
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