Since insulin is directly involved in the uptake of glucose into tissue, and that glucose uptake by muscle can increase seven- to twentyfold during exercise insulin concentration decreases during exercise of increasing intensity. This is important because if exercise was associated with an increase in insulin, the plasma glucose would be taken up into all tissues (including adipose tissue) at a faster rate, leading to an immediate hypoglycemia. Adipose tissue fatty acid release would also be lower and fatty acids couldn't be used as a fuel. Lower concentration of insulin during exercise favors the mobilisation of glucose from the liver and makes blood glucose homeostasis possible.This is very interesting topic and you should have several things in mind. You should carefully monitor other hormones concentration since insulin is not the only one involved in glucose homeostasis. Moreover, you should also have catecholamines in mind. The insulin response is diffeent in different types of exercise, gender, age,... Difference is observable between trained and non-traied subjects!!To really approach this problem well you have to think about ways muscle (and other) cells can take up glucose without insulin and difference in insulin sensitivity during exercise and during rest. I hope this helped. I will also attach graph - A) change inthe plasma insulin concentration with increasing intensitiesof exercise and B) percent change (from resting values)
in the plasma insulin concentration during prolonged
exercise at 60%Vo2 max (showing the effect of endurance
training on that response) from Exercise physiology (Powers,Howley).
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