PI3K catalyzes the synthesis of the secondmessenger phosphatidylinositol 3,4,5 triphosphate (PIP3) from phosphatidylinositol 4,5 bisphosphate (PIP2), wherein the membranebound PIP3 serves as a signaling molecule to recruit proteins containing the pleckstrin homology (PH) domain. These PH domain proteins,such as the phosphoinositide-dependent protein kinase (PDK) andprotein kinase B (AKT) serine/threonine kinases, are thus activatedand mediate further downstream signaling events
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