The histological features show a typical GNET, a trabecular or solid arrangement. Tumor cells are monomorphic and medium sized, of regular shape with round nuclei. Mitoses are either absent or are seen occasionally. Tumor extension is limited to the mucosa or submucosa. The gastrin-dependent GNETs are consistently associated with generalized proliferation of endocrine cells in the extratumoral fundic mucosa. A histopathological classification has been formulated for the spectrum of proliferative lesions presented by fundic endocrine cells of hypergastrinemic patients; it arranges type I tumors in a sequence presumed to reflect the temporal evolution of the process and the increasing oncologic risk for patients[19]. Diagnosis of GNETs requires efficient histopathological, biochemical and diagnostic imaging analyses
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