Kekkai Sensen adapts a select 12 chapters from the first 6 volumes of the manga it is based on while adding a new plotline and characters, culminating in an anime-exclusive ending. Aside from the first episode which adapts the three-chapter pilot, each episode adapts one chapter.
Episodes 1 and 2 were previewed at a screening at Odaiba Cinema Mediage in Tokyo on March 21, 2015. Regular broadcasting began on April 5, 2015. The final episode was originally scheduled to broadcast on July 4, 2015, but was delayed to October 4, 2015.