in none of the hundreds ofanimals injected with chymopapain have we found arachnoiditis
at necropsy. When chymopapain is injected intrathecally in sufficient quantity to be toxic,
it causes bleeding from the poorly supported vessels of the pia-arachnoid and the animal
usually dies in a few hours with increased intracranial pressure. The toxicity produced appears
to be a haemorrhagic pressure phenomenon and may be alleviated. For example, lethal dose
in 50 per cent of dogs after intrathecal injection is 025 milligram per kilogram.
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