allow GN to be categorized into subgroups correlating with other features of the disease. Three patterns emerge. 1. Antiglomerular basement membrane ( anti-GBM ) antibody disease (eg, Goodpasture syndrome): This disease results from the development of circulating antibodies to an antigen intrinsic to the glomerular basement membrane. Binding of these pathologic anti-GBM antibodies to the glomerular basement membrane causes a cascade of inflammation. Light microscopy shows crescentic GN, and characteristic linear immunoglobulin deposition in the glomerular capillaries is seen on immunofluorescence.
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