activation. These results suggest that α-mangostin inhibits Ca2+-ATPase to induce apoptosis through the mitochondrial pathway in the cells [30]. GML extract-induced SKBR3 human breast cancer cell line early apoptosis was accompanied by the production of reactive oxygen species (ROS). This was not surprising because the accumulation of intracellular ROS is one of the important mechanisms leading to early apoptosis..
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