Glucosamine (Fig. 1 ) is an amino sugar occurring naturally inthe body, acting as a precursor of glycosaminoglycans which aremajor components of joint cartilage. Supplemental glucosamineis believed to prevent cartilage degeneration and to treat arthritis [1–3]. Glucosamine is commonly formulated as glucosaminesulfate or glucosamine hydrochloride in combination with othernutraceutical supplements such as chondroitin sulfate and methylsulfonylmethane [4]. In study of the biological role of glucosamineand for quality control in drug production, an accurate and reliable method for analysis of glucosamine in biological fluids andpharmaceutical formulations is required
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