The outer periphery of the dentin is greater at the periphery than at the pulp-dentin border , especially in the crown part of tooth. since the dentinal tubules are cylindrical in shape and extend through the entire width of the dentin , the density of tubules is greater near the pulp than peripherally. In addition the branching of the tubules varies in different parts of teeth resulting in distinct differences in the structure of dentin . These differences are likely to affect the permeability of the tissue . In addition , post eruptive changes take place in dentin as by pathological processes like caries throughout the life of the tooth . In this review emphasis will be placed of the structural changes the affect the permeability of the tissue.The dental pulp is one of a few tissue in the body that exhibit a normal relatively high interstitial tissue fluid pressure. This means that a pressure gradient exits in dentinal tubules under normal conditions . Anything trying to penetrate through the dentin towards the pulp must do againts a pressure gradient while anything penetrating from the pulp will be facilitated by the same pressure gradient can be imitated in vitro by using an experimental design to compensate for the pressure
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