The English botanist, chemist, and physician SirWilliam Withering is credited with the first publishedobservation in 1785 that digitalis purpurea, a derivative of the purple foxglove flower, could be used for thetreatment of “cardiac dropsy,” or congestive heart failure. The benefits of cardiac glycosides in CHF havebeen extensively studied (Eichhorn and Gheorghiade,2002) and are generally attributed to: • Inhibition of the plasma membrane Na+, K+-ATPasein myocytes• A positive inotropic effect on the failing myocardium• Suppression of rapid ventricular rate response in CHF- associated atrial fibrillation • Regulation of downstream deleterious effects ofsympathetic nervous system overactivation
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