The anti-babesial action of primaquine found in this study confirmed the results reported by Potgieter18. Primaquine had a dramatic effect on parasitaemia, particu-larly in control cats 2 and 3 (Fig. 1). Primaquine failed to sterilise the infec-tions, however: 2 of the cats still yielded parasites on blood smear examination 12 months after conclusion of the trial.For 2 days after the 1st administration of buparvaquone it appeared as if the drug would have similar anti-babesial proper-ties to primaquine. On the 3rd day, when the 2nd treatment was administered, the parasitaemia in both cats began to rise rapidly, increasing to such a level that they had to be removed from the trial. After treatment with primaquine, the PCV of both cats took c. 48 h longer to recover than that of the control cats. Buparvaquone is therefore not regarded as suitable for the treatment of B. felis infection.Rifampicin appeared to have an anti-parasitic effect, preventing the parasitae-mia from increasing but not causing it to decrease substantially. The sustained de-crease in PCV despite stabilisation of the parasitaemia renders rifampicin unsuit-able for treating B. felis infections.The response to treatment with sulpha-diazine-trimethoprim was very similar to that recorded for rifampicin. The parasi-taemia stabilised or gradually decreased, but this was accompanied by a dramatic
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