METHAMPHETAMINE FAQ v1.0:1. via Chl

METHAMPHETAMINE FAQ v1.0:

1. via Chloromethamphetamine notes
with Bromomethamphetamine extension.
2. via Iodomethamphetamine notes
3. P2P notes [none yet other than "reductively aminate"]
4. via D-Phenylalanine notes
[or DL-Phenylalanine]
5. via Amphetamine
6. Seperation of isomers of amphetamine and related
7. "Bunk" synthesises, and why they don't work
8. General information

...........................(1) Via Chloromethamphetamine...................

Making it from ephedrine or pseudoephedrine is possible. The only
difference between methamphetamine and (pseudo)ephedrine is that damn
alpha-hydroxy group. Reacting your ephedrine with thionyl chloride
replaes the OH with Cl to produce N-methyl-alpha-chloroamphetamine as an
intermediate. Hydrogenating this product is easy: use lithium aluminum
hydride, sodium borohydride, or even hydrogen gas with nickel or platinum
metal as a catalyst. The product of this step is N-methylamphetamine and
HCl. Evaporate off the water and you have methamphetamine hydrochloride.

Another method:
React the (pseud)Ephedrine with PHOSPHORUS PENTACHLORIDE (maybe even
the trichloride would work!). This is another chlorinating agent. The
byproduct is phosphoric acid instead of messy sulphur compounds. In other
words, LESS STINK!!!
Reduction is possible with standard LAH procedures, as per above.
/////////////////////A bromomethamphetamine side note, possibly appliable
to the chloroamphetamine methods with altered yields///////
> Would you be so kind as to e-mail me a detailed description of the
> brominated ephedrine method of synthesizing methamphetamine. Thanx!
Method, no. The idea I proposed was to prepare HBr acid [see elusis's
file] in aqueous solution, add Ephedrine base (or HBr?) and zinc bromide
[or a small amount of zinc to FORM zinc bromide] as catalyst, to form
bromomethamphetamine. This reaction would take place faster than the
coresponding reaction with HCl.
note that HI + ZnI may very well proceed straight to methamphetamine
given HI's aptitude for attacking iodated hydrocarbons.
The bromomethamphetamine would be disolved in anhydrous ethyl ether, then
powdered magnesium would be added, hopefully forming the grignard. To
this water is added slowly to form methamphetamine and various magnesium
salts..
I've never seen it tried and the NH2+ may cause a problem with forming the
grignard. It's just an idea.


............................(2) Via Iodomethamphetamine....................

(pseud)Ephedrine is reduced with red phosphorus using iodine as a catalyst.

OK, remember the reagent for halide sub. of an alcohol?
It was always PCl3, PBr3, or PI3 right?
Neat P(x)3 isn't usually used, right?

So, I imagine you would mix HI, red P, and the alcohol in a flask at first.
Then the P4 would change to PI3. (no, not by magic. do you remember this
shit yet?) The PI3 would reduce the alcohol to a halide by some mech. I
forgot. The PI3 again magically changes to H3PO3 and HI when heated.
The HI reduces the alcohol-that-is-now-a-halide to a hydrocarbon.

SO... The reaction basically goes like this:

Phosphorus + Iodine ---> PI3
(pseud)Ephedrine + PI3 ---> Phosphoric acid + b-Iodo,n-methamphetamine
PI3 + water ---> HI + H3PO3
b-Iodo,n-methamphetamine + HI ---> Methamphetamine + I2 (iodine)
(iodine is reused)

Another version of this synthesis involves reacting iodine with plain
old red phosphorus, adding the ephedrine, then continuing to add red P
to keep the reduction going. This is the 'classic biker meth' recipe,
and without a good acid/base extraction thru a nonpolar solvent, a good
way to end up a hyperthyroid mess with the nickname 'goiter joe']. Since,
nou doubt, the classic "biker methheads" eyeballed amounts for their
reagents [just kidding guys], and evaluated production not with scales and
chromatographs but with HONEST TO GOD FIELD TESTING [heh heh] of the
compound, there were no amounts listed. Figure it out yerself, as directed
to in the below listing:
///////////////////////////////////////////////////////////////////////////
This whole thread has been extremely educational to an old P2P chemHacker
like POPEYE, but I think y'all need to know that the HI reduction of
ephedrine doesn't involve a chlorephedrine intermediate or hydrogenation w/
Pd/C, Raney Nickel,and especially not LAH.
Now I could be fullaShit, BUT, it seems that at LEAST two syntheses are
being confused here.
The original question was:
> Will hydroiodic acid really reduce ephedrine to methamphetamine via
> beta-iodo-methamphetamine?
POPEYE doesn't know shit about anything following the 'via' in that
sentence, but he does know that L-ephedrine is refluxed with hydriodic acid
in the presence of a RED PHOSPHOROUS catalyst for 32 hours to yield crank
oil, which is seperated from the reaction goop with 10% LYE and a sep
funnel, then acidified, dehydrated, and cooled in an ether-acetone
solution to yield Crystal.. much simpler than Yall are makin' it out to be.
This is the famous one-step biker crank and it's killer when done as an art
form...considerably more potent than a P2P route and absoLUTEly the reason
that L-ephedrine has become scarce in some sectors of the occupied
territories formerly known as the USA.
Sorry I couldn't supply references or proportions for this synth....It
should be easy to Mole out from what I've said, and I absolutely 100% can
guarantee that this is not bullshit.
\\\\\\\\\\\\\\\\\\


Always watch out for beta-halogenated byproduct - these unreacted components
are supposedly quite bad for you. A LAH wash of the finished compound should
remove them nicely. Barring that, a quick reflux in 1M NaOH(aq) will probably
convert any beta-halogenated product back into ephedrine - strive to use
enough phosphorus to complete the original reaction.

YET ANOTHER METHOD:
Alcohols can be converted to their halides simply by mixing with the acid.
Tert-butanol reacts SO FAST that merely mixing it with HCl results in tert-
butyl-chloride in a few minutes! In general, the rules for this are that
tertiary alcohols react fastest, and primary alcohols slowest. N-butanol +
HCl reacts so slowly that Zinc Chloride must be used as a catalyst. Another
thing to remember is that HI reacts fastest, HCl slowest.

With this in mind, recall that Hx halogen acids can be synthesized from
their salts and a stronger acid. Sulphuric acid is suitable for HCl and
sometimes HBr, but will oxidize HI back to I2. Phosphoric acid however will
not, and can be used with solid KI or NaI to make HI gas.

The ideal reaction to use for this method would probably involve zinc iodide
and hydroiodic acid. Zinc iodide can be prepared by simply mixing zinc and
iodine in a suitable setting and heating (dangerous enough - exothermic rxn).
Make enough zinc iodide and you can use it...
Zinc Iodide + Phosphoric acid ---> Zinc Phosphate + HI (gas)

ZnI
HI + Ephedrine ---> b-iodomethamphetamine + H2O

HI + b-iodomethamphetamine ---> methamphetamine

A suggested synthesis would involve leaving the HI + Ephedrine over ZnI
for for a LONG TIME [two days?], perhaps even with heating? As with
all proposed synthesises, try it first, find out, and use your intuition
to think of an improvement, try that, see if it works better or worse, etc.


...................................(3) P2P Notes...........................


.............................(4) Via D,L-Phenylalanine.....................

A surprisingly simple synthesis is possible from the amino acid
phenylalanine, which is available at health food stores for about $14 for
100 tablets. Phenylalanine is 2-amino-3-phenylpropanoic acid, which is
more or less amphetamine with a COOH where the CH3 should be at the end of
the chain. Thionyl chloride will replace the OH with a Cl, which falls off
and is replaced by H when you give it lithium aluminum hydride, sodium
borohydride, or hydrogen gas and nickel/platinum. If you use hydrogen and
metal for that step, you'll have to reduce the carbonyl group with one of
the hydrides, so best save time + effort and use them and do both
reductions at once. When that carbonyl is reduced, you now have
amphetamine. Go back up to that first one I mentioned for upgrading
amphetamine into methamphetamine. (and end up with a racemic mixture - that
is to say dl-amphetamine or dl-methamphetamine - the latter being similar
to 50% d-meth from ephedrine and 50% l-meth from a vicks inhaler!]
[BY THE WAY: If you use the all-to-common L-Phenylalanine, you'll get
l-amphetamine! Use "DL-Phenylalanine (DLPA)" if you want to use this
prcedure]

Note that both the DLPA and the P2P procedures will give you a mixture
of d- and l- isomers. The d- is cool, the l- is shit. If you have the
time, energy, and equipment, you can separate the two.

|and reprocess the l- into d- by oxidizing it and re-aminating it as
|described in the "critique" of the Phrack synthesis.
Why bother? what a major pain in the ass, especially considering the
ease of producing the d-isomer directly, the cheapness of DLPA versus
recycling L-meth into more racemic product, etc. Simply isolate
the D-isomer and THROW the L-isomer AWAY!!!


................................(5) Via Amphetamine........................

One of the easiest ways to make methamphetamine is from amphetamine. Of
course, this assumes you have amphetamine in the first place, but let's
just pretend you have some and you want to spice it up a bit.
The difference between amphetamine and methamphetamine is the addition of
a single methyl group (CH3) to the amino group sticking off the middle
carbon atom in the chain. Fortunately, substituting amines is really
simple. Vaporize your amine (your amphetamine) with a bunch of vaporized
chloromethane (CH3Cl, a solvent) and some gaseous pyridine...
voila, the amino group takes the methyl from the chlorometha

Kết quả (Việt) 1:

METHAMPHETAMINE FAQ v1.0:1. via Chloromethamphetamine notes with Bromomethamphetamine extension.2. via Iodomethamphetamine notes3. P2P notes [none yet other than "reductively aminate"]4. via D-Phenylalanine notes [or DL-Phenylalanine]5. via Amphetamine6. Seperation of isomers of amphetamine and related7. "Bunk" synthesises, and why they don't work8. General information...........................(1) Via Chloromethamphetamine...................Making it from ephedrine or pseudoephedrine is possible. The only difference between methamphetamine and (pseudo)ephedrine is that damn alpha-hydroxy group. Reacting your ephedrine with thionyl chloride replaes the OH with Cl to produce N-methyl-alpha-chloroamphetamine as an intermediate. Hydrogenating this product is easy: use lithium aluminum hydride, sodium borohydride, or even hydrogen gas with nickel or platinum metal as a catalyst. The product of this step is N-methylamphetamine and HCl. Evaporate off the water and you have methamphetamine hydrochloride.Another method:React the (pseud)Ephedrine with PHOSPHORUS PENTACHLORIDE (maybe eventhe trichloride would work!). This is another chlorinating agent. Thebyproduct is phosphoric acid instead of messy sulphur compounds. In otherwords, LESS STINK!!!Reduction is possible with standard LAH procedures, as per above./////////////////////A bromomethamphetamine side note, possibly appliable to the chloroamphetamine methods with altered yields///////> Would you be so kind as to e-mail me a detailed description of the > brominated ephedrine method of synthesizing methamphetamine. Thanx!Method, no. The idea I proposed was to prepare HBr acid [see elusis's file] in aqueous solution, add Ephedrine base (or HBr?) and zinc bromide [or a small amount of zinc to FORM zinc bromide] as catalyst, to form bromomethamphetamine. This reaction would take place faster than the coresponding reaction with HCl. note that HI + ZnI may very well proceed straight to methamphetamine given HI's aptitude for attacking iodated hydrocarbons.The bromomethamphetamine would be disolved in anhydrous ethyl ether, then powdered magnesium would be added, hopefully forming the grignard. To this water is added slowly to form methamphetamine and various magnesium salts..I've never seen it tried and the NH2+ may cause a problem with forming the grignard. It's just an idea.............................(2) Via Iodomethamphetamine....................(pseud)Ephedrine is reduced with red phosphorus using iodine as a catalyst.OK, remember the reagent for halide sub. of an alcohol?It was always PCl3, PBr3, or PI3 right?Neat P(x)3 isn't usually used, right?So, I imagine you would mix HI, red P, and the alcohol in a flask at first.Then the P4 would change to PI3. (no, not by magic. do you remember this shit yet?) The PI3 would reduce the alcohol to a halide by some mech. I forgot. The PI3 again magically changes to H3PO3 and HI when heated.The HI reduces the alcohol-that-is-now-a-halide to a hydrocarbon.SO... The reaction basically goes like this:Phosphorus + Iodine ---> PI3(pseud)Ephedrine + PI3 ---> Phosphoric acid + b-Iodo,n-methamphetaminePI3 + water ---> HI + H3PO3b-Iodo,n-methamphetamine + HI ---> Methamphetamine + I2 (iodine) (iodine is reused)Another version of this synthesis involves reacting iodine with plain old red phosphorus, adding the ephedrine, then continuing to add red Pto keep the reduction going. This is the 'classic biker meth' recipe, and without a good acid/base extraction thru a nonpolar solvent, a good way to end up a hyperthyroid mess with the nickname 'goiter joe']. Since,nou doubt, the classic "biker methheads" eyeballed amounts for theirreagents [just kidding guys], and evaluated production not with scales andchromatographs but with HONEST TO GOD FIELD TESTING [heh heh] of thecompound, there were no amounts listed. Figure it out yerself, as directedto in the below listing:///////////////////////////////////////////////////////////////////////////This whole thread has been extremely educational to an old P2P chemHackerlike POPEYE, but I think y'all need to know that the HI reduction ofephedrine doesn't involve a chlorephedrine intermediate or hydrogenation w/Pd/C, Raney Nickel,and especially not LAH.Now I could be fullaShit, BUT, it seems that at LEAST two syntheses arebeing confused here.Câu hỏi ban đầu là:> Sẽ hydroiodic axít thực sự giảm ephedrin để methamphetamine via > Phiên bản beta-iodo-methamphetamine?POPEYE không biết shit về bất cứ điều gì sau các 'qua' trong đócâu, nhưng ông biết rằng L-ephedrin refluxed với hydriodic axitsự hiện diện của một chất xúc tác phốt pho đỏ cho 32 giờ để mang lại quâydầu, đó là tách ra từ goop phản ứng với 10% LYE và một tháng chínKênh, sau đó acidified, mất nước, và làm mát bằng nước trong một ête-axetongiải pháp để mang lại tinh thể... đơn giản hơn nhiều so với Yall Makin ' nó được.Đây là nổi tiếng One-Bước biker quây và nó là kẻ giết người khi thực hiện như là một nghệ thuậthình thức... đáng kể hơn mạnh hơn so với một tuyến đường P2P và hoàn toàn có lý doL-ephedrin đã trở nên khan hiếm trong một số lĩnh vực của chiếmlãnh thổ trước đây gọi là Hoa Kỳ.Xin lỗi tôi không thể cung cấp tài liệu tham khảo hoặc tỷ lệ cho synth này... Nónên được dễ dàng để nốt ruồi ra từ những gì tôi đã nói, và tôi hoàn toàn 100% có thểđảm bảo rằng đây không phải là nhảm nhí.\\\\\\\\\\\\\\\\\\Luôn luôn xem ra cho phiên bản beta-halogenated sản phẩm phụ - các thành phần unreactedcho là khá xấu cho bạn. Một rửa LAH của các hợp chất hoàn thành nênloại bỏ chúng độc đáo. Ngăn cản rằng, một trào ngược nhanh chóng trong 1M NaOH(aq) sẽ có thểchuyển đổi bất kỳ phiên bản beta-halogenated sản phẩm trở lại vào ephedrin - phấn đấu để sử dụngđủ phốt pho để hoàn thành phản ứng ban đầu.ĐƯỢC MỘT PHƯƠNG PHÁP:Rượu có thể được chuyển đổi sang các halua của họ chỉ đơn giản bằng cách trộn với axit.Tert-butanol reacts SO FAST that merely mixing it with HCl results in tert-butyl-chloride in a few minutes! In general, the rules for this are thattertiary alcohols react fastest, and primary alcohols slowest. N-butanol + HCl reacts so slowly that Zinc Chloride must be used as a catalyst. Anotherthing to remember is that HI reacts fastest, HCl slowest.With this in mind, recall that Hx halogen acids can be synthesized fromtheir salts and a stronger acid. Sulphuric acid is suitable for HCl andsometimes HBr, but will oxidize HI back to I2. Phosphoric acid however willnot, and can be used with solid KI or NaI to make HI gas.The ideal reaction to use for this method would probably involve zinc iodideand hydroiodic acid. Zinc iodide can be prepared by simply mixing zinc andiodine in a suitable setting and heating (dangerous enough - exothermic rxn).Make enough zinc iodide and you can use it...Zinc Iodide + Phosphoric acid ---> Zinc Phosphate + HI (gas) ZnIHI + Ephedrine ---> b-iodomethamphetamine + H2OHI + b-iodomethamphetamine ---> methamphetamineA suggested synthesis would involve leaving the HI + Ephedrine over ZnIfor for a LONG TIME [two days?], perhaps even with heating? As with all proposed synthesises, try it first, find out, and use your intuitionto think of an improvement, try that, see if it works better or worse, etc....................................(3) P2P Notes...........................

.............................(4) Via D,L-Phenylalanine.....................

A surprisingly simple synthesis is possible from the amino acid
phenylalanine, which is available at health food stores for about $14 for
100 tablets. Phenylalanine is 2-amino-3-phenylpropanoic acid, which is
more or less amphetamine with a COOH where the CH3 should be at the end of
the chain. Thionyl chloride will replace the OH with a Cl, which falls off
and is replaced by H when you give it lithium aluminum hydride, sodium
borohydride, or hydrogen gas and nickel/platinum. If you use hydrogen and
metal for that step, you'll have to reduce the carbonyl group with one of
the hydrides, so best save time + effort and use them and do both
reductions at once. When that carbonyl is reduced, you now have
amphetamine. Go back up to that first one I mentioned for upgrading
amphetamine into methamphetamine. (and end up with a racemic mixture - that
is to say dl-amphetamine or dl-methamphetamine - the latter being similar
to 50% d-meth from ephedrine and 50% l-meth from a vicks inhaler!]
[BY THE WAY: If you use the all-to-common L-Phenylalanine, you'll get
l-amphetamine! Use "DL-Phenylalanine (DLPA)" if you want to use this
prcedure]

Note that both the DLPA and the P2P procedures will give you a mixture
of d- and l- isomers. The d- is cool, the l- is shit. If you have the
time, energy, and equipment, you can separate the two.

|and reprocess the l- into d- by oxidizing it and re-aminating it as
|described in the "critique" of the Phrack synthesis.
Why bother? what a major pain in the ass, especially considering the
ease of producing the d-isomer directly, the cheapness of DLPA versus
recycling L-meth into more racemic product, etc. Simply isolate
the D-isomer and THROW the L-isomer AWAY!!!


................................(5) Via Amphetamine........................

One of the easiest ways to make methamphetamine is from amphetamine. Of
course, this assumes you have amphetamine in the first place, but let's
just pretend you have some and you want to spice it up a bit.
The difference between amphetamine and methamphetamine is the addition of
a single methyl group (CH3) to the amino group sticking off the middle
carbon atom in the chain. Fortunately, substituting amines is really
simple. Vaporize your amine (your amphetamine) with a bunch of vaporized
chloromethane (CH3Cl, a solvent) and some gaseous pyridine...
voila, the amino group takes the methyl from the chlorometha