The independenta priori specification of regions of interest was based on previous studies of Tower of London and Spatial Rotations Tasks (Williams-Gray et al., 2007b; Hampshire et al., 2012). Beta values in eighta prioriregions of interest were extracted: right dorso-lateral prefrontal cortex (DLPFC), left DLPFC, right frontopolar cortex,bilateral posterior parietal cortex and precuneus. Additionally, caudate nuclei (right caudate:x=10,y= 15,z= 2; left caudate:x=10, y= 15,z= 2, 10 mm radius sphere) were included because of their high relevance within the frontostriatal network in mediating executive functions in healthy controls (Owen et al., 1996) and Parkinson’s dis-ease (Lewiset al., 2003). A task-specific region of interest template for Memory Encoding Task (Hampshireet al., 2012) was based on inde-pendent 60 healthy control data: bilateral hippocampus (right hippocampus, left hippocampus), left superior parietal gyrus, right inferior frontal gyri pars triangularis and pars opercularis, left inferiorfrontal gyrus, left occipital and a large region of interest including posterior temporo-parieto-occipital area.
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