a Department of Geriatrics, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi ,Kochi783-8505,Japan b- Department of Chemical & Petroleum Engineering, University of Pittsburgh, 1249 Benedum Hall, Pittsburgh, PA15261, USA c Department of Phytochemistry, Shenyang Pharmaceutical University, No. 103, Wenhua Road,Shenyang110015,China d Department of Chemistry,Kochi Medical School,Kohasu, Oko-cho, Nankoku-shi, Kochi 783- 8505, Japan Received 13 September 1999; received in revised form 29 December 1999; accepted 14 January 2000
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