Putting this knowledge in perspective of receptor structure andassembly indicates that e.g. for the α4 β2 a slowing down of the α4synthesis might yield receptors that contain a higher fraction of β2.Since the expression of different ratios of mRNAs or cDNAs encodingfor α4 and β2 yield functional receptors displaying distinct physiological and pharmacological properties, this implies that getting abetter knowledge of the inter-individual variations of DNA is moreimportant than initially thought. This is best exemplified by the recentfinding of an association between a silent mutation and a disease(Hurst, 2011 ).
đang được dịch, vui lòng đợi..
