In some animals, hemoglobincirculates as free protein in the plasma and isnot enclosed in RBCs. When it is free in the plasma ofthe human being, about 3 percent of it leaks through thecapillary membrane into the tissue spaces or through theglomerular membrane of the kidney into the glomerularfiltrate each time the blood passes through the capillaries.Therefore, hemoglobin must remain inside RBCs to effectivelyperform its functions in humans
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