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Vaccines

Saturday, March 31, 2012, 15:30 - 16:30
Comparison of the side effects seen after rabies postexposure prophylaxis with two different verocell vaccines

T. Sari, N. Tulek, F. Temocin, F.S. Erdinc, C. Bulut, G. Tuncer Ertem*, B. Oral (Ankara, TR)
Objective: In our country, rabies prophylaxis has been implemented according to the guideline of Turkish Ministry of Health (Either Zagreb regimen with 2-1-1 vaccination protocol alone or Essen regimen with 5 doses vaccination with rabies immunoglobulin (RIG). Although human rabies cases were apparently declined in recent years, more than a hundred thousand of people have been receiving postexposure prophylaxis per year because of rabies- risk-contact in our country. In this study, the side effects of rabies vaccines were investigated and compared according to the schedules and brand names.
Methods: Rabies vaccine applied patients for postexposure prophylaxis at our center in 2010 were included into the study. All patients were followed up to the end of schedule. The adverse events were compared according to the age, gender of the patients, the type of the vaccine and the schedule used.
Results: A total of 1685 patients (1089 male, 596 female) were vaccinated. The Essen regimen with equine RIG was applied to 265 patients (15.7%) and Zagreb regimen was applied to 1420 patients (84.3%). A verocell vaccine, Verorab (Sanofi Pasteur) was used in 761(45.2%) patients and Abhayrab (Indian Immunologicals Ltd.) also a verocell vaccine was used in 924 patients (54.8%). All side effects were higher in female patients. The patients were divided in three groups, according to ages as; the first group 0-15 years, the second 15-60 years and above 60 years. Whereas fever (21.2%), vomiting (2.4%) and coughing (2.1%) were significantly higher in the first group, headache (8.8%) and joint pain (6.7%) were significantly higher in the second group compared to the other two groups (p

Kết quả (Việt) 1:

Trang chủ - 31.03.2012 - vắc xinVắc xinThứ bảy, 31 Tháng ba, 2012, 15:30-16:30So sánh các tác dụng phụ thấy sau khi bệnh dại postexposure dự phòng với hai khác nhau verocell vắc xinT. sari, N. Tulek, F. Temocin, FS Erdinc, C. Bulut, G. Tuncer Ertem *, sinh răng miệng (Ankara, TR)Mục tiêu: Ở nước ta, Phòng ngừa bệnh dại đã được thực hiện theo các hướng dẫn của bộ y tế Thổ Nhĩ Kỳ (hoặc Zagreb chế độ 2-1-1 giao thức tiêm phòng một mình hoặc Essen chế độ với 5 liều tiêm phòng với bệnh dại globulin miễn dịch (giàn khoan). Mặc dù trường hợp của con người bệnh dại đã được rõ ràng từ chối những năm gần đây, nhiều hơn một trăm nghìn người đã nhận được postexposure sản mỗi năm vì nguy cơ-bệnh dại tiếp xúc ở nước ta. Trong nghiên cứu này, các tác dụng phụ của bệnh dại vắc xin đã được điều tra và so sánh theo lịch trình và thương hiệu. Phương pháp: Bệnh nhân bệnh dại vắc xin được áp dụng cho các phòng ngừa postexposure tại Trung tâm của chúng tôi vào năm 2010 đã được đưa vào nghiên cứu. Tất cả bệnh nhân được theo dõi để cuối cùng của lịch trình. Các sự kiện bất lợi đã so sánh theo độ tuổi, giới tính của các bệnh nhân, loại vắc-xin và lịch trình sử dụng. Results: A total of 1685 patients (1089 male, 596 female) were vaccinated. The Essen regimen with equine RIG was applied to 265 patients (15.7%) and Zagreb regimen was applied to 1420 patients (84.3%). A verocell vaccine, Verorab (Sanofi Pasteur) was used in 761(45.2%) patients and Abhayrab (Indian Immunologicals Ltd.) also a verocell vaccine was used in 924 patients (54.8%). All side effects were higher in female patients. The patients were divided in three groups, according to ages as; the first group 0-15 years, the second 15-60 years and above 60 years. Whereas fever (21.2%), vomiting (2.4%) and coughing (2.1%) were significantly higher in the first group, headache (8.8%) and joint pain (6.7%) were significantly higher in the second group compared to the other two groups (p<0.05). All side effects were more frequent with first doses of each type of vaccine and those were more frequent after the first doses of 2-1-1 regimen. All side effects were higher after Zagreb regimen than Essen (p<0.05). Fever (15.8% vs 10.6%), local pain (6.6% vs 2.6%), headache (7.5% vs 3%), fatique (10.2% vs 4.5%) and arthralgia (4.9% vs 1.5%) were the most common complaints, respectively. Fever (23.8% vs 4.8%), fatigue (13.6% vs 4.6%), headache (9.7% vs 3.1%), local pain (8.9% vs 2.5) and arthralgia (6.8% vs 3.1%) were significantly higher with Abhayrab than Verorab, respectively. Conclusion: As a result, each of the vaccines seemed safe but although they are both verocell vaccines, side effects seen may vary according to the product and regimen.