3.1 Molecular StructureThe alemtuzumab structure consists of two 24 kD light polypeptide chains (L-C) and two 49 kD heavy polypeptide chains (H-C) linked together by two interdisulfide (L-C)-(H-C) bridges and two interdisulfide (H-C)-(H-C) bridges to form a Y-shaped molecule (see Figure 3.1). Each molecule also contains a total of 12 intrachain disulfide bridges and an asparagine residue in each heavy chain that is amenable to glycosylation.20Figure 3.1: Drug Molecular Structure
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