It turns out the answer isn't so simple, according to a report in The New York Times. About 10 years ago, Ahmed El-Sohemy, PhD, a professor of nutritional sciences at the University of Toronto, decided to look at a particular gene, called CYP1A2, involved in the metabolism of caffeine, and how it might affect coffee's impact on the heart.People who inherit two copies of the "fast" variant of CYP1A2, one from each parent, are known as "fast metabolizers," and can break down caffeine about four times more quickly than folks who inherit two copies of the slow variant of CYP1A2. In a study done with 4,000 adults, El-Sohemy and his colleagues found that consuming four or more cups of coffee per day was associated with a 36% increased risk of heart attack. But once the researchers accounted for the gene variants, they found that the increased risk only applied to the slow caffeine metabolizers. Among the fast caffeine metabolizers, people who drank up to three cups of coffee a day had a lower risk of a heart attack.
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