Fig. 2. Dietary antioxidants, such as the preservatives sodium sulfite and sodiumbenzoate or the colorant curcumin, have been shown to interfere with signaling cascades that regulate food intake (Ciardi et al., 2012). Blocking IDO activity stabilizesperipheral tryptophan levels, and simultaneous reductions of leptin release negatively interfere with satiety regulation. Both of these effects trigger food intake, thuspromoting the development of obesity.
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