Fentanyl citrate is incompatible with alkaline solutions (due to reduced solubility) and some drugs.Published data show that Fentanyl 50 micrograms/ml Solution for Injection/Infusion is incompatible with alkaline injections including methohexital and thiopental.Loss of fentanyl citrate due to absorption to PVC containers has been reported when the solution pH was adjusted to the alkaline range (but see section 6.6).Compatibility must be checked before administration.
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