These compounds have little industrial use and in general are oily liquids of low solubility and volatility.
Toxicologically, they can be classified as moderate irritants, because their anesthetic symptoms are
mild. Unsaturated compounds may be absorbed via the skin to a significant extent, while the saturated
chemicals are not. Halogenation produces definite skin irritation, some systemic absorption and,
therefore, toxicity. Aromatic nitro compounds are a class of chemicals, several members of which may
produce methemoglobin formation and/or sensitization to the compound.
Nitro derivatives of benzene and toluene also have prominent toxic effects other than sensitization,
CNS depression, or methemoglobinemia. The trinitrotoluene or dinitrobenzene compounds are well
absorbed by all routes of exposure. These compounds can uncouple oxidative phosphorylation, and
liver injury is often seen along with the toxicities previously mentioned. Other problems that have been
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