Fig. 2 Cytochrome P450 secondary structure and substrate recognitionsites The different helices are marked as the six differentsubstrate recognition sequences (SRS). In CYP2D6 the SRS correspondto the following amino acids: SRS1:100–125; SRS2:213–219; SRS3:239–246; SRS4: 294–312; SRS5:369–375; SRS6:480–487
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