METHAMPHETAMINE FAQ v1.0:1. via Chl

METHAMPHETAMINE FAQ v1.0:

1. via Chloromethamphetamine notes
with Bromomethamphetamine extension.
2. via Iodomethamphetamine notes
3. P2P notes [none yet other than "reductively aminate"]
4. via D-Phenylalanine notes
[or DL-Phenylalanine]
5. via Amphetamine
6. Seperation of isomers of amphetamine and related
7. "Bunk" synthesises, and why they don't work
8. General information

...........................(1) Via Chloromethamphetamine...................

Making it from ephedrine or pseudoephedrine is possible. The only
difference between methamphetamine and (pseudo)ephedrine is that damn
alpha-hydroxy group. Reacting your ephedrine with thionyl chloride
replaes the OH with Cl to produce N-methyl-alpha-chloroamphetamine as an
intermediate. Hydrogenating this product is easy: use lithium aluminum
hydride, sodium borohydride, or even hydrogen gas with nickel or platinum
metal as a catalyst. The product of this step is N-methylamphetamine and
HCl. Evaporate off the water and you have methamphetamine hydrochloride.

Another method:
React the (pseud)Ephedrine with PHOSPHORUS PENTACHLORIDE (maybe even
the trichloride would work!). This is another chlorinating agent. The
byproduct is phosphoric acid instead of messy sulphur compounds. In other
words, LESS STINK!!!
Reduction is possible with standard LAH procedures, as per above.
/////////////////////A bromomethamphetamine side note, possibly appliable
to the chloroamphetamine methods with altered yields///////
> Would you be so kind as to e-mail me a detailed description of the
> brominated ephedrine method of synthesizing methamphetamine. Thanx!
Method, no. The idea I proposed was to prepare HBr acid [see elusis's
file] in aqueous solution, add Ephedrine base (or HBr?) and zinc bromide
[or a small amount of zinc to FORM zinc bromide] as catalyst, to form
bromomethamphetamine. This reaction would take place faster than the
coresponding reaction with HCl.
note that HI + ZnI may very well proceed straight to methamphetamine
given HI's aptitude for attacking iodated hydrocarbons.
The bromomethamphetamine would be disolved in anhydrous ethyl ether, then
powdered magnesium would be added, hopefully forming the grignard. To
this water is added slowly to form methamphetamine and various magnesium
salts..
I've never seen it tried and the NH2+ may cause a problem with forming the
grignard. It's just an idea.


............................(2) Via Iodomethamphetamine....................

(pseud)Ephedrine is reduced with red phosphorus using iodine as a catalyst.

OK, remember the reagent for halide sub. of an alcohol?
It was always PCl3, PBr3, or PI3 right?
Neat P(x)3 isn't usually used, right?

So, I imagine you would mix HI, red P, and the alcohol in a flask at first.
Then the P4 would change to PI3. (no, not by magic. do you remember this
shit yet?) The PI3 would reduce the alcohol to a halide by some mech. I
forgot. The PI3 again magically changes to H3PO3 and HI when heated.
The HI reduces the alcohol-that-is-now-a-halide to a hydrocarbon.

SO... The reaction basically goes like this:

Phosphorus + Iodine ---> PI3
(pseud)Ephedrine + PI3 ---> Phosphoric acid + b-Iodo,n-methamphetamine
PI3 + water ---> HI + H3PO3
b-Iodo,n-methamphetamine + HI ---> Methamphetamine + I2 (iodine)
(iodine is reused)

Another version of this synthesis involves reacting iodine with plain
old red phosphorus, adding the ephedrine, then continuing to add red P
to keep the reduction going. This is the 'classic biker meth' recipe,
and without a good acid/base extraction thru a nonpolar solvent, a good
way to end up a hyperthyroid mess with the nickname 'goiter joe']. Since,
nou doubt, the classic "biker methheads" eyeballed amounts for their
reagents [just kidding guys], and evaluated production not with scales and
chromatographs but with HONEST TO GOD FIELD TESTING [heh heh] of the
compound, there were no amounts listed. Figure it out yerself, as directed
to in the below listing:
///////////////////////////////////////////////////////////////////////////
This whole thread has been extremely educational to an old P2P chemHacker
like POPEYE, but I think y'all need to know that the HI reduction of
ephedrine doesn't involve a chlorephedrine intermediate or hydrogenation w/
Pd/C, Raney Nickel,and especially not LAH.
Now I could be fullaShit, BUT, it seems that at LEAST two syntheses are
being confused here.
The original question was:
> Will hydroiodic acid really reduce ephedrine to methamphetamine via
> beta-iodo-methamphetamine?
POPEYE doesn't know shit about anything following the 'via' in that
sentence, but he does know that L-ephedrine is refluxed with hydriodic acid
in the presence of a RED PHOSPHOROUS catalyst for 32 hours to yield crank
oil, which is seperated from the reaction goop with 10% LYE and a sep
funnel, then acidified, dehydrated, and cooled in an ether-acetone
solution to yield Crystal.. much simpler than Yall are makin' it out to be.
This is the famous one-step biker crank and it's killer when done as an art
form...considerably more potent than a P2P route and absoLUTEly the reason
that L-ephedrine has become scarce in some sectors of the occupied
territories formerly known as the USA.
Sorry I couldn't supply references or proportions for this synth....It
should be easy to Mole out from what I've said, and I absolutely 100% can
guarantee that this is not bullshit.
\\\\\\\\\\\\\\\\\\


Always watch out for beta-halogenated byproduct - these unreacted components
are supposedly quite bad for you. A LAH wash of the finished compound should
remove them nicely. Barring that, a quick reflux in 1M NaOH(aq) will probably
convert any beta-halogenated product back into ephedrine - strive to use
enough phosphorus to complete the original reaction.

YET ANOTHER METHOD:
Alcohols can be converted to their halides simply by mixing with the acid.
Tert-butanol reacts SO FAST that merely mixing it with HCl results in tert-
butyl-chloride in a few minutes! In general, the rules for this are that
tertiary alcohols react fastest, and primary alcohols slowest. N-butanol +
HCl reacts so slowly that Zinc Chloride must be used as a catalyst. Another
thing to remember is that HI reacts fastest, HCl slowest.

With this in mind, recall that Hx halogen acids can be synthesized from
their salts and a stronger acid. Sulphuric acid is suitable for HCl and
sometimes HBr, but will oxidize HI back to I2. Phosphoric acid however will
not, and can be used with solid KI or NaI to make HI gas.

The ideal reaction to use for this method would probably involve zinc iodide
and hydroiodic acid. Zinc iodide can be prepared by simply mixing zinc and
iodine in a suitable setting and heating (dangerous enough - exothermic rxn).
Make enough zinc iodide and you can use it...
Zinc Iodide + Phosphoric acid ---> Zinc Phosphate + HI (gas)

ZnI
HI + Ephedrine ---> b-iodomethamphetamine + H2O

HI + b-iodomethamphetamine ---> methamphetamine

A suggested synthesis would involve leaving the HI + Ephedrine over ZnI
for for a LONG TIME [two days?], perhaps even with heating? As with
all proposed synthesises, try it first, find out, and use your intuition
to think of an improvement, try that, see if it works better or worse, etc.


...................................(3) P2P Notes...........................


.............................(4) Via D,L-Phenylalanine.....................

A surprisingly simple synthesis is possible from the amino acid
phenylalanine, which is available at health food stores for about $14 for
100 tablets. Phenylalanine is 2-amino-3-phenylpropanoic acid, which is
more or less amphetamine with a COOH where the CH3 should be at the end of
the chain. Thionyl chloride will replace the OH with a Cl, which falls off
and is replaced by H when you give it lithium aluminum hydride, sodium
borohydride, or hydrogen gas and nickel/platinum. If you use hydrogen and
metal for that step, you'll have to reduce the carbonyl group with one of
the hydrides, so best save time + effort and use them and do both
reductions at once. When that carbonyl is reduced, you now have
amphetamine. Go back up to that first one I mentioned for upgrading
amphetamine into methamphetamine. (and end up with a racemic mixture - that
is to say dl-amphetamine or dl-methamphetamine - the latter being similar
to 50% d-meth from ephedrine and 50% l-meth from a vicks inhaler!]
[BY THE WAY: If you use the all-to-common L-Phenylalanine, you'll get
l-amphetamine! Use "DL-Phenylalanine (DLPA)" if you want to use this
prcedure]

Note that both the DLPA and the P2P procedures will give you a mixture
of d- and l- isomers. The d- is cool, the l- is shit. If you have the
time, energy, and equipment, you can separate the two.

|and reprocess the l- into d- by oxidizing it and re-aminating it as
|described in the "critique" of the Phrack synthesis.
Why bother? what a major pain in the ass, especially considering the
ease of producing the d-isomer directly, the cheapness of DLPA versus
recycling L-meth into more racemic product, etc. Simply isolate
the D-isomer and THROW the L-isomer AWAY!!!


................................(5) Via Amphetamine........................

One of the easiest ways to make methamphetamine is from amphetamine. Of
course, this assumes you have amphetamine in the first place, but let's
just pretend you have some and you want to spice it up a bit.
The difference between amphetamine and methamphetamine is the addition of
a single methyl group (CH3) to the amino group sticking off the middle
carbon atom in the chain. Fortunately, substituting amines is really
simple. Vaporize your amine (your amphetamine) with a bunch of vaporized
chloromethane (CH3Cl, a solvent) and some gaseous pyridine...
voila, the amino group takes the methyl from the chlorometha

Kết quả (Việt) 1:

Hỏi đáp METHAMPHETAMINE v1.0:1. qua Chloromethamphetamine ghi chú với phần mở rộng Bromomethamphetamine.2. qua Iodomethamphetamine ghi chú3. P2P lưu ý [không có nhưng khác hơn là "reductively aminate"]4. qua D-nmol ghi chú [hoặc DL-nmol]5. qua Amphetamine6. tách các đồng phân của amphetamine và liên quan7. "tầng" synthesises, và tại sao họ không làm việc8. tổng hợp thông tin........................... (1) thông qua Chloromethamphetamine...Làm cho nó từ ephedrin hoặc pseudoephedrine có thể. Duy nhất sự khác biệt giữa ephedrin methamphetamine và (giả) là chết tiệt đó Nhóm alpha hydroxy. Phản ứng của bạn ephedrin với thionyl clorua replaes OH với Cl để sản xuất N-methyl-alpha-chloroamphetamine như là một Trung cấp. Hydrogenating sản phẩm này rất dễ dàng: sử dụng liti nhôm hydrua, borohiđrua natri hoặc thậm chí các khí hiđrô với niken hoặc bạch kim kim loại như là một chất xúc tác. Các sản phẩm của bước này là N-methylamphetamine và HCl. Evaporate ra khỏi nước, và bạn có methamphetamine Hiđrôclorua.Một phương pháp khác:Phản ứng (pseud) ephedrin với PENTACLORUA PHỐTPHO (thậm chí có thểtriclorua sẽ làm việc!). Đây là một chlorinating. Cácsản phẩm phụ là axít phốtphoric thay vì hợp chất lưu huỳnh lộn xộn. Kháclời nói, ít mùi hôi!Giảm có thể với các thủ tục tiêu chuẩn LAH, như một ở trên.Một lưu ý phụ bromomethamphetamine, có thể appliable phương pháp chloroamphetamine với sản lượng thay đổi / / /> Bạn sẽ loại như vậy là để e-mail cho tôi một mô tả chi tiết của các > brôm ephedrin phương pháp tổng hợp methamphetamine. Thanx!Phương pháp, không có. Ý tưởng tôi đề nghị là để chuẩn cho HBr axit [xem của elusis tập tin] trong dung dịch nước, thêm ephedrin cơ sở (hoặc HBr?) và kẽm bromua [hoặc một số lượng nhỏ của kẽm để tạo thành kẽm bromua] như là chất xúc tác, hình thành bromomethamphetamine. Phản ứng này sẽ diễn ra nhanh hơn so với các coresponding phản ứng với HCl. lưu ý rằng HI + ZnI có thể rất tốt tiến thẳng tới methamphetamine đưa HI của aptitude để tấn công iodated hydrocarbon.Bromomethamphetamine sẽ disolved Khan ethyl ether, sau đó magnesium bột sẽ được thêm vào, Hy vọng tạo thành grignard. Để nước này được thêm vào từ từ dạng methamphetamine và nhiều magiê muối...Tôi đã không bao giờ nhìn thấy nó đã cố gắng và NH2 + có thể gây ra một vấn đề với hình thành các Grignard. Đó là chỉ là một ý tưởng............................. (2) thông qua Iodomethamphetamine...(pseud) Ephedrin giảm với phốt pho đỏ sử dụng iốt như một chất xúc tác.OK, hãy nhớ rằng tinh khiết cho halua sub. một rượu?Nó luôn luôn là Pbr3, PBr3, hoặc PI3 right?Gọn gàng P (x) 3 không phải là thường được sử dụng, phải không?Vì vậy, tôi tưởng tượng bạn sẽ kết hợp HI, đỏ P và rượu trong một flask lúc đầu tiên.Sau đó P4 sẽ thay đổi để PI3. (không, chứ không phải bởi magic. bạn có nhớ này chết tiệt chưa?) PI3 sẽ làm giảm rượu đến halua một bởi một số mech. Tôi forgot. The PI3 again magically changes to H3PO3 and HI when heated.The HI reduces the alcohol-that-is-now-a-halide to a hydrocarbon.SO... The reaction basically goes like this:Phosphorus + Iodine ---> PI3(pseud)Ephedrine + PI3 ---> Phosphoric acid + b-Iodo,n-methamphetaminePI3 + water ---> HI + H3PO3b-Iodo,n-methamphetamine + HI ---> Methamphetamine + I2 (iodine) (iodine is reused)Another version of this synthesis involves reacting iodine with plain old red phosphorus, adding the ephedrine, then continuing to add red Pto keep the reduction going. This is the 'classic biker meth' recipe, and without a good acid/base extraction thru a nonpolar solvent, a good way to end up a hyperthyroid mess with the nickname 'goiter joe']. Since,nou doubt, the classic "biker methheads" eyeballed amounts for theirreagents [just kidding guys], and evaluated production not with scales andchromatographs but with HONEST TO GOD FIELD TESTING [heh heh] of thecompound, there were no amounts listed. Figure it out yerself, as directedto in the below listing:///////////////////////////////////////////////////////////////////////////This whole thread has been extremely educational to an old P2P chemHackerlike POPEYE, but I think y'all need to know that the HI reduction ofephedrine doesn't involve a chlorephedrine intermediate or hydrogenation w/Pd/C, Raney Nickel,and especially not LAH.Now I could be fullaShit, BUT, it seems that at LEAST two syntheses arebeing confused here.The original question was:> Will hydroiodic acid really reduce ephedrine to methamphetamine via > beta-iodo-methamphetamine?POPEYE doesn't know shit about anything following the 'via' in thatsentence, but he does know that L-ephedrine is refluxed with hydriodic acidin the presence of a RED PHOSPHOROUS catalyst for 32 hours to yield crankoil, which is seperated from the reaction goop with 10% LYE and a sepfunnel, then acidified, dehydrated, and cooled in an ether-acetonesolution to yield Crystal.. much simpler than Yall are makin' it out to be.This is the famous one-step biker crank and it's killer when done as an artform...considerably more potent than a P2P route and absoLUTEly the reasonthat L-ephedrine has become scarce in some sectors of the occupiedterritories formerly known as the USA.Sorry I couldn't supply references or proportions for this synth....Itshould be easy to Mole out from what I've said, and I absolutely 100% canguarantee that this is not bullshit.\\\\\\\\\\\\\\\\\\Always watch out for beta-halogenated byproduct - these unreacted componentsare supposedly quite bad for you. A LAH wash of the finished compound shouldremove them nicely. Barring that, a quick reflux in 1M NaOH(aq) will probablyconvert any beta-halogenated product back into ephedrine - strive to useenough phosphorus to complete the original reaction.YET ANOTHER METHOD:Alcohols can be converted to their halides simply by mixing with the acid.Tert-butanol reacts SO FAST that merely mixing it with HCl results in tert-butyl-chloride in a few minutes! In general, the rules for this are thattertiary alcohols react fastest, and primary alcohols slowest. N-butanol + HCl reacts so slowly that Zinc Chloride must be used as a catalyst. Anotherthing to remember is that HI reacts fastest, HCl slowest.With this in mind, recall that Hx halogen acids can be synthesized fromtheir salts and a stronger acid. Sulphuric acid is suitable for HCl andsometimes HBr, but will oxidize HI back to I2. Phosphoric acid however willnot, and can be used with solid KI or NaI to make HI gas.The ideal reaction to use for this method would probably involve zinc iodideand hydroiodic acid. Zinc iodide can be prepared by simply mixing zinc andiodine in a suitable setting and heating (dangerous enough - exothermic rxn).Make enough zinc iodide and you can use it...Zinc Iodide + Phosphoric acid ---> Zinc Phosphate + HI (gas) ZnIHI + Ephedrine ---> b-iodomethamphetamine + H2OHI + b-iodomethamphetamine ---> methamphetamineA suggested synthesis would involve leaving the HI + Ephedrine over ZnIfor for a LONG TIME [two days?], perhaps even with heating? As with all proposed synthesises, try it first, find out, and use your intuitionto think of an improvement, try that, see if it works better or worse, etc....................................(3) P2P Notes........................................................(4) Via D,L-Phenylalanine.....................A surprisingly simple synthesis is possible from the amino acidphenylalanine, which is available at health food stores for about $14 for100 tablets. Phenylalanine is 2-amino-3-phenylpropanoic acid, which ismore or less amphetamine with a COOH where the CH3 should be at the end ofthe chain. Thionyl chloride will replace the OH with a Cl, which falls offand is replaced by H when you give it lithium aluminum hydride, sodiumborohydride, or hydrogen gas and nickel/platinum. If you use hydrogen andmetal for that step, you'll have to reduce the carbonyl group with one ofthe hydrides, so best save time + effort and use them and do bothreductions at once. When that carbonyl is reduced, you now haveamphetamine. Go back up to that first one I mentioned for upgradingamphetamine into methamphetamine. (and end up with a racemic mixture - thatis to say dl-amphetamine or dl-methamphetamine - the latter being similar to 50% d-meth from ephedrine and 50% l-meth from a vicks inhaler!][BY THE WAY: If you use the all-to-common L-Phenylalanine, you'll get l-amphetamine! Use "DL-Phenylalanine (DLPA)" if you want to use this prcedure]Note that both the DLPA and the P2P procedures will give you a mixture of d- and l- isomers. The d- is cool, the l- is shit. If you have the time, energy, and equipment, you can separate the two. |and reprocess the l- into d- by oxidizing it and re-aminating it as |described in the "critique" of the Phrack synthesis.Why bother? what a major pain in the ass, especially considering the ease of producing the d-isomer directly, the cheapness of DLPA versusrecycling L-meth into more racemic product, etc. Simply isolate the D-isomer and THROW the L-isomer AWAY!!!................................(5) Via Amphetamine........................One of the easiest ways to make methamphetamine is from amphetamine. Of course, this assumes you have amphetamine in the first place, but let's just pretend you have some and you want to spice it up a bit.The difference between amphetamine and methamphetamine is the addition of a single methyl group (CH3) to the amino group sticking off the middle carbon atom in the chain. Fortunately, substituting amines is really simple. Vaporize your amine (your amphetamine) with a bunch of vaporized chloromethane (CH3Cl, a solvent) and some gaseous pyridine...voila, the amino group takes the methyl from the chlorometha