severe damage to the glomerular capillaries. This appears to be a nonspecific final pathway in a variety of glomerular diseases. Recovery without specific treatment is rare. RPGN appears to be a heterogeneous group of disorders, all of which display pathologic features common to various categories of necrotizing vasculitis ( Table 16–10 ; also see later discussion). 2. Chronic glomerulonephritis is characterized by persistent urinary abnormalities and slowly progressive (years) decline in renal function. Chronic GN does not typically resolve. Progressive renal deterioration in patients with chronic GN proceeds inexorably, resulting in CKD up to 20 years after initial discovery of an abnormal urinary sediment. 3. Nephrotic syndrome manifests as marked proteinuria, particularly albuminuria (defined as 24-hour urine
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