Pathophysiology When the mitral valve fails to close properly, regurgitationof blood into the left atrium from the ventricle occurs duringsystole. In chronic mitral regurgitation, the compensatorymechanism to this volume load is similar to the changes seenin aortic regurgitation. The left ventricle and atrium dilate,and to normalize wall stress in the ventricle there is alsoconcomitant hypertrophy of the ventricular wall (see priordiscussion of Laplace law). Diastolic filling of the ventricleincreases because it is now the sum of right ventricular output
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