Physiological Determinants of Vaso-occlusion in the KidneyResearch on renal vaso-occlusion is limited to two studies that suggest severe medullary hypertonia causes sequestration of SQ RBCs in the kidney (3, 17). These studies did not adequately assess effects of modest tubular hypertonia and no study has evaluated the importance of mixed arterial hypertonia or inflammation to renal vaso-occlusion. InSpecific Aim 1, we adapt the isolated rat kidney model used in these original studies (3, 17) to determine effects of tubular hypertonia, and mixed arteriolar hypertonia and renal inflammation on kidney micro vaso-occlusion...etc.
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