The effect of cadmium exposure in drinking water on mark- ers of oxidative stress in rat cardiac tissue has shown significantly increased lipoperoxides, MDA and decreased activities of SOD andglutathione peroxidase (GPx) (Novelli et al., 2000). No alterations were observed in catalase activity. In addition, decreased glucose levels and increased total lipid content in cardiac tissue of rats following cadmium exposure were observed. The decreased activ- ities of alanine transaminase and aspartate transaminase reflected decreased metabolic protein degradation and increased lactate dehydrogenase activity. Since the metabolic pathways were altered by cadmium exposure, it can be concluded that Cd2+-induced for- mation of ROS initiates a series of events that occur in the heart which in turn resulted in alterations of metabolic pathways.
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