This result suggests that VRN2 modulates the quantitative levels of FT (directly or indirectly), providing a link between the vernalization pathway and FT in the temperate cereals. This genetic interaction is not completely unexpected, because the CCT domain in VRN2 is related to the one present in CO, which was shown to be involved in the regulation of FT transcript levels (35). It is tempting to speculate that the allelic differences in the FT regulatory regions described in this study may be responsible for the disruption of the interactions between FT and VRN2 (ora VRN2-regulated gene) and for their differential responses to the vernalization treatment. A tentative model summarizing the interactions between VRN1, VRN2, and VRN3 is presented inFig. 4.
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