WHAT IS CITRULLINE MALATE?Citrulline is an amino acid that is produced when the amino acid ornithine combines with carbamoyl phosphate. This happens during the urea cycle, a way that the body disposes of nitrogen waste. The excess citrulline from supplementation is thought to put the urea cycle into overdrive, sucking up the ammonia (made of three nitrogen molecules) produced by working muscles before it can produce fatigue.Citrulline is also a by-product of the body's conversion of the amino acid arginine into nitric oxide (NO). Excess citrulline, a number of studies have shown, increases the amount of arginine in the blood, leading to increased NO production. More NO, you may have heard, means increased blood flow to muscles during exercise, which allows them to last longer under duress—and produce bigger muscle pumps to weightlifters.Malate, or malic acid, is a salt compound that is often used as a food preservative and, in nature, contributes to the sour flavor of apples and other fruit. In supplemental form, it is bound to citrulline and other various other supplements to give them stability in the body.However, malate is also thought to have fatigue-fighting capabilities of its own, by helping the body recycle lactic acid and use it for energy.
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